Quality records · 5 min read
HPLC and mass spectrometry: what each record shows
An introduction to the distinct information these commonly referenced analytical records provide.
Chromatographic records
An HPLC chromatogram displays detector response over retention time under a stated method. Review the method, integration approach, reported area percentages, and whether all relevant peaks are shown.
Mass records
Mass spectrometry data compares detected mass-to-charge signals with expected molecular information. Review the ionization method, reported species, and interpretation supplied with the record.
Avoid over-reading a single result
A chromatographic purity value is not the same as identity, concentration, sterility, or suitability. Each conclusion requires an appropriate method and documented acceptance criteria.